Prenatal androgen excess impairs beta-cell function by decreased sirtuin 3 expression

Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially pancreatic beta-cell function, is rarely investigated. Our current study mainly focused effects prenatal metabolism and beta- cell function aged By using mice their offspring as animal models, we found that treatment induced obesity intolerance These influences were accompanied by decreased fasting serum insulin concentration, elevated triglyceride, concentrations. Glucose stimulated secretion beta cells was also affected exposure. We further confirmed increased contributed to downregulation sirtuin 3 expression, activated oxidative stress, impaired Moreover, over-expression islets isolated from treated with normalized stress level, restored cyclic AMP, ATP generation, which finally improved glucose-stimulated cells. Taken together, these results demonstrated caused a disturbance via suppression expression activation